Silver Nanoparticle Based Multifunctional Approach for Combating COVID-19

Dr. Deborah Sharing Important Information

Many thanks to Dr. Deborah for sharing, saying,

On Fri, Oct 20, 2023, at 5:41 PM Dr. Deborah wrote:

Hi Terral:

If no one listens to the Dutch lady maybe they will read this: good graphics here.

For what it’s worth...or not :-)

I am out for now. Nature time.

Blessings, Deborah

My comments are posted below with a reply to Isa’s question and recommendations. Everyone is advised to do your research for determining what is best for you and your families, as we approach what Dr. Ana characterizes as an Extinction-Level Event (Greg Hunter Interview).

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Silver nanoparticle based multifunctional approach for combating COVID-19

https://doi.org/10.1016/j.sintl.2021.100101Get rights and content

Under a Creative Commons license open access

Prince Allawadhi ^{a 1}, Vishakha Singh ^{b 1}, Amit Khurana ^{c d e}, Isha Khurana ^f, Sachin Allwadhi ^g, Pawan Kumar ^h, Anil Kumar Banothu ^{d i}, Sunitha Thalugula ^j, Percy Jasmine Barani ^k, Ramavath Redya Naik ^l, Kala Kumar Bharani

Highlights

• Silver nanoparticles (AgNPs) possess promising antimicrobial, antiviral and immunomodulatory activity.

• AgNPs of size 2–15 nm are reported to potently inhibit the entry of SARS-CoV-2 virus inside the host cells.

• AgNPs offer superior antimicrobial and antiviral efficacy compared to its elemental counterpart.

• AgNPs may even reduce the complications of SARS-CoV-2 infection by suppression of cytokines, MAPKs and NFκB signaling.

• AgNPs can aid in COVID-19 diagnosis by incorporation in accurate diagnostic kits.

Abstract

COVID-19 is a highly contagious and widespread disease that has strained the global healthcare system to the hilt. Silver nanoparticles (AgNPs) are well known for their potent antimicrobial, antiviral, immunomodulatory and biosensing properties. AgNPs have been found to be potential antiviral agent that act against many deadly viruses and is presumed to be effective against COVID-19. AgNPs can generate free radicals and reactive oxygen species (ROS) leading to apoptosis mediated cell death thereby inhibiting viral infection. The shape and size of AgNPs play an important role in its biomedical applications as alterations may result in variable biological interaction and activity. Herein, we propose that AgNPs can be utilized for effective management of the ongoing COVID-19 pandemic by highlighting the current status of AgNPs in the fight against COVID-19.

Graphical abstract

Keywords:

Silver nanoparticles, COVID-19, Antiviral activity, Antimicrobial, Cytokine storm

1. Introduction

In December 2019, in Wuhan city of China, clusters of pneumonia cases similar to the severe acute respiratory syndrome (SARS) were reported, which was caused by a newly discovered strain of coronavirus (CoV) [1]. Subsequently, the disease was named COVID-19, and the virus involved in this disease was designated as SARS-CoV-2 [2]. Coronaviruses comprise of a big class of viruses that consists of a core of genetic material (single-stranded RNA genome) enveloped by a spherical lipid layer with spikes like protein structure attached to the surface. This structure gives it a crown-like appearance, and in Latin, corona means crown, so this is why, these viruses are labelled as coronaviruses [3,4]. The genomic sequence of this new virus is 78.5% similar to that of the previously known SARS-CoV. However, SARS-CoV-2 transmits faster than SARS-CoV [[5], [6], [7]]. The SARS-CoV-2 virion contains structural proteins namely spike, envelope, membrane, and nucleocapsid. The RNA genome of the virion is encapsulated by the nucleocapsid, while membrane and envelop protein in assembly process confirm its incorporation into the viral particle. Spike protein has specificity towards the host entry receptors i.e., the spike protein interacts with the host angiotensin-converting enzyme 2 (ACE2), along with host factors like cell surface serine protease namely transmembrane protease, serine 2 (TMPRSS2) which stimulates the uptake and fusion of the virus at host cellular membrane [8]. The positive sense RNA genome has two open reading frames (ORFs) i.e., ORF1a and ORF1b. The translation of ORF1a results in the formation of polyproteins (pp) pp1a and pp1ab which are processed into sixteen non-structural proteins (nsps) by post-translational and co-translational modifications. The non-structural proteins are responsible for forming viral replication and transcription complex. The translated structural proteins are translocated to the membranes of endoplasmic reticulum (ER) followed by transit via ER to the golgi complex intermediatory compartment (ERGIC) where production of new viral genomic RNA takes place leading into the budding of virions. Lastly, virions are released from the host via exocytosis as shown in Fig. 1 [9,10]. Currently, most of the treatments for COVID-19 management are given for symptomatic relief and support the respiratory system of seriously ill patients [11,12]. Though, the many vaccines including Sputnik-V and BNT162b2 have been granted emergency use authorization, their safety remains unclear and the recent complications including the disputed cases of Bell's palsy with BNT162b2, indicate the enormity of risk involved in approving vaccines in a haste [[13], [14], [15]]. The need of the present time is to develop and design potent antiviral agents that may aid in fighting and overcoming the COVID-19 pandemic [[16], [17], [18]].

Metals including calcium, iron, selenium and zinc play crucial role in a number of vital biochemical reactions which are essential for growth and survival [[19], [20], [21]]. Though, silver (Ag) is not an essential element, it is an important element of biomedical importance. Nanoparticles (NPs) are well known for their numerous advantages including increased surface area, tailored release profile of the cargo, modulation of drug pharmacokinetics, reduced toxicity and improved biological response [22,23]. AgNPs are considered as one of the potential therapeutic nanoparticles and are included in most commercialized NPs considering their distinctive catalytic, optical and clinical applications. AgNPs can induce immunologic response and cause inflammatory cell apoptosis in the host. Silver is used in a significant number of Ayurvedic formulations including fortified Chyavanprash and Bhasmas (fine metal powders claimed to be of nano size). The silver Bhasma has been traditionally used for the treatment of inflammation, pain, memory improvement and other diseases. Further, silver has been reported to be beneficial against a variety of inflammatory, cardiovascular and other non-communicable disorders [19,[24], [25], [26], [27]]. Silver possesses potent antimicrobial and immunomodulatory effects and its nano form has been reported to attenuate the progression of multiple diseases including diabetes [28]. Some of the marketed products based on silver are PolyMem Silver™ (Aspen), Acticoat™ and Bactigras™ (Smith & Nephew), Tegaderm™ (3 M) and Aquacel™ (ConvaTec) [29].

Continue: https://www.sciencedirect.com/science/article/pii/S266635112100022X

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On Thu, Oct 19, 2023 at 11:16 AM Isa wrote:

Yesterday I watched a VDO where Sabrina Wallace mentions about your silver might help a "specific" group of people, but not necessary effective for everybody (I believe she means as protection from or de-activating the nano-tech) and that she has to dig deeper into the product. Do you know what she meant with "only effective for some people (hybridized individuals?)

Terral’s reply (10.22.2023 at 6:52AM):

Hi Isa:

Thank you for writing. Tony and Sabrina do not know enough about the Nano Silver - Sodium Borate regimen and the benefits to have an opinion one way or the other. Sabrina is trying to pacify members of what appears to be some kind of cult, IMHO, in respect for Tony. Follow the discussion on Substack for more info.

Blessings, Terral

More and More Tony-Sabrina followers are taking advantage of the opportunity to get on the Nano Silver - Sodium Borate regimen for neutralizing bioweapon threats like many Terral03.com supporters have been doing for years. Many of you have questions relating to information coming from Tony and Sabrina that you really need to be sending to them for their clarifying statements.

I make a living providing threat assessment and contingency planning for survival group members around the world that includes information on Project Black Star, the Superplume growing out of control in the Earth Mantle Transition Zone, the SARS binary bioweapons, bioweapon Vax, and other viral-bacterial-fungal threats expected when the peanut butter hits the fan. I also help Christians see God’s wisdom hidden in plain sight using God’s three witnesses of spirit, blood, and water using the lessons from The Mystery Explained and the six intro videos shared in the Scripture Section at https://www.terral03.com.

Subscribe and/or purchase your Nano Silver and write to me at the email address provided in your notification emails, and I will do my best to help you. I highly recommend Sabrina and her work for helping you to see and understand how AI manipulates the nanobots and other bioweapon Vax components inside your unprotected body. If you want people like Tony and Sabrina to be your threat assessment-contingency planning analysts for helping you and your family devise the very best survival strategy possible, then a good idea is for you to send your comments, questions, and concerns to them.

My recommendation is that everyone be on the Nano Silver - Sodium Borate Weight Chart regimen for neutralizing bioweapon threats. Get yourself and your family a good supply for when the peanut butter hits the fan and have one gallon of distilled water available for each 2-ounce bottle with the 500ppm concentration.

Our time is short and my time is spent helping my supporters and prepping for what is coming, and for what is almost here. Get more information by reading my original posts and my comments. Blessings, Terral